In dermatology, cyclosporine is used to quiet down the inflammation in the skin by its effect on certain immune cells (lymphocytes).

The dose is usually 2-5 mg per kg of body weight, and the medication should be taken with a full glass of water at the same time each day; generally, after breakfast and dinner. It is highly recommended not to take this with grapefruit juice because in may unpredictably increase the amount of cyclosporine absorbed in your blood stream.

It is essential to follow your doctors advice regarding this medication.

We will be monitoring your blood pressure, kidney function, complete blood count, liver function, lipid levels, and uric acid.

Certain medications should be avoided by patients on cyclosporine.

If it is necessary to receive treatment with one of the following medications, please let your medical team know.

• Non-steroidal antiinflammatory drugs, such as Indocin, Naproxine, Advil, etc.

• Antibiotics, such as trimethoprim, Bactrim, sulfa, rifampin, erythromycin, Cipro, gentamicin, and tobramicin.

• Antieleptics, such as phenytoin, Dilantin, carbamazepine.

• Antifungals, such as Ketoconazole, itraconazole, fluconazole, amphotericin B, and St. John's Wort.

• Hypertension, which may require the addition of a new medication to control your blood pressure.
• Reduced renal function. If this does occur, it may require reducing the dose of cyclosporine or possibly, stopping it.
• Increased hair growth. You may have to shave your hair more often. There is a new cream called Vaniqua, which may be used as an epilating agent to remove your hair if this should occur.
• Decreased appetite or nausea.
• Parethesia. This feels like pins and needles on the fingers, or toes, or lips. This is a rare side effect.
• Tremor
• Swollen gums or bleeding gums. It is recommended that you brush and floss daily. Keep regular dental check ups.
• Increased risk for bacterial, viral, and fungal infection. Please see your doctor if you are not feeling well.
• Possible increased risk for cancer, particularly, skin cancer. Protect yourself from over exposure to the sun. It is not recommended that you undergo phototherapy while you are on cyclosporine.

Cyclosporine is a very effective drug in the treatment of certain severe skin conditions. Once your skin condition has stablized, we will advise you to slowly reduce your daily dose of this medication. Over time, we will rotate you to another form of therapy.